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KMID : 0379520020180040349
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한국독성학회지
2002 Volume.18 No. 4 p.349 ~ p.354
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Genotoxicity Studies of DA-6034, a New Flavonoid Derivative
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Kang Byeong-Cheol
Kwon Eun-A
Lee Na-Rae
Ahn Byoung-Ok
Kim Won-Bae
Lee Sang-Koo
Lee Kook-Hyun
Chung Jin-Ho
Sung Myung-Whun
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Abstract
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Inflammatory bowel disease (IBD) is a multifactorial disorder with unknown etiology and pathogenesis. Eupatilin, a kind of flavonoids, has been known to be effective for chronic diarrhea in Korea. In this study, we have investigated the genotoxicity of DA-6034, a new synthetic derivative of Eupatilin, wing in vitro and in viuo system such as Ames reverse mutation test, chromosomal aberration test and micronucleus test. in Ames reverse mutation test, DA-6034 treatment at the dose range up to 5,000 mutextrm{g}/ plate did not induced mutagenicity in Salmonella typhimurium TA98, TA100, TA102, TA1535, TA1537 with and without metabolic activation. Any significant aberration wasn’t observed in chinese hamster lung(CHL) fibroblast cells treated with DA-6034 at the concentration of 5, 2.5, 1.25 mg/ml both in the absence and presence of metabolic activation system. In mouse micronucleus test, no significant increase in the occurrence of micronucleated polychromatic erythrocytes was observed in ICR male mice orally administered with DA-6034 of the doses of 2.0, 1.0, 0.5 g/kg. These results indicate that DA-6034 has no mutagenic potential under the condition in this study.
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KEYWORD
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Genotoxicity, DA-6034, reverse mutation, chromosomal aberration, micronucleus
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